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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $32 | In Stock | |
5 mg | $70 | In Stock | |
10 mg | $100 | In Stock | |
25 mg | $163 | In Stock | |
50 mg | $238 | In Stock | |
100 mg | $355 | In Stock | |
1 mL x 10 mM (in DMSO) | $87 | In Stock |
Description | (R)-CR8 trihydrochloride (CR8, (R)-Isomer trihydrochloride) is a CDK1/2/5/7/9 inhibitor that acts as a molecular glue degrader with neuroprotective activity and induces apoptosis. |
In vitro | In the SH-SY5Y cell line, (R)-CR8 trihydrochloride (0.1, 1, 10, 100 μM; 24 hours) reduced cell survival in a dose-dependent manner[1]. |
In vivo | In 10 to 12-week-old male Sprague-Dawley rats (310 to 330 g), administration of (R)-CR8 trihydrochloride at 5 mg/kg (i.p.) resulted in a significant reduction in lesion size[2]. |
Alias | CR8, (R)-Isomer trihydrochloride |
Molecular Weight | 540.92 |
Formula | C24H32Cl3N7O |
Cas No. | 1786438-30-9 |
Storage | keep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year | ||||||||||||||||||||||||||||||
Solubility Information | DMSO: 30 mg/mL (55.46 mM) | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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